Reaction Details  Report a problem with these data
Target
Transcription initiation factor TFIID subunit 1 [1504-1635]
Ligand
BDBM346540
Substrate
n/a
Meas. Tech.
AF1-BD2 TR-FRET Binding Assay
IC50
20.1±n/a nM
Citation
 Adler, M; Burdick, DJ; Crawford, T; Duplessis, M; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Tsui, VH; Wang, S Therapeutic compounds and uses thereof US Patent  US10202378 Publication Date 2/12/2019
Target
Name:
Transcription initiation factor TFIID subunit 1 [1504-1635]
Synonyms:
BA2R | CCG1 | CCGS | TAF1 | TAF1-BD2 (11 1504-1635) | TAF1-BD2 (aa 1504-1635) | TAF1_HUMAN | TAF2A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15296.09
Organism:
Homo sapiens (Human)
Description:
P21675[1504-1635]
Residue:
132
Sequence:
QVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLD
  
Inhibitor
Name:
BDBM346540
Synonyms:
(1-acetyl-4-piperidyl)methyl4-(3-hydroxy-3-methyl-but-1-ynyl)-2,6-dimethyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-3-carboxylate | US10202378, Example 144
Type:
Small organic molecule
Emp. Form.:
C23H29N3O5
Mol. Mass.:
427.4935
SMILES:
CC(=O)N1CCC(COC(=O)c2c(C)[nH]c3c2c(cn(C)c3=O)C#CC(C)(C)O)CC1
Structure:
Search PDB for entries with ligand similarity: