Target

Ligand

Substrate

Meas. Tech.

Kinase assays for IC50 determinations

pH

7.5±n/a

Temperature

303.15±n/a K

Citation

 Foloppe, N; Fisher, LM; Francis, G; Howes, R; Kierstan, P; Potter, A Identification of a buried pocket for potent and selective inhibition of Chk1: prediction and verification. Bioorg Med Chem 14:1792-804 (2006) [PubMed]  Article

More Info.:

Get all data from this article,   Solution Info,  Assay Method

Name:

Serine/threonine-protein kinase Chk1

Synonyms:

CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

54443.02

Organism:

Homo sapiens (Human)

Description:

gi_166295192

Residue:

476

Sequence:

MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM16589

Synonyms:

4-[3-(1H-1,3-benzodiazol-2-yl)-1H-indazol-6-yl]-2-methoxyphenol | 4-[3-(1H-benzimidazol-2-yl)-1H-indazol-6-yl]-2-methoxyphenol | Indazole Compound 1

Type:

Small organic molecule

Emp. Form.:

C21H16N4O2

Mol. Mass.:

356.3773

SMILES:

COc1cc(ccc1O)-c1ccc2c(n[nH]c2c1)-c1nc2ccccc2[nH]1

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

Chktide

Synonyms:

n/a

Type:

Peptide

Mol. Mass.:

2707.16

Organism:

n/a

Description:

n/a

Residue:

23

Sequence:

KKKVSRSGLYRSPSMPENLNRPR