Reaction Details  Report a problem with these data
Target
Carbonic anhydrase 5A, mitochondrial
Ligand
BDBM16649
Substrate
BDBM10856
Meas. Tech.
Esterase Assay
Ki
96±n/a nM
Citation
 Vullo, D; Franchi, M; Gallori, E; Antel, J; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides. J Med Chem 47:1272-9 (2004) [PubMed]  Article
Target
Name:
Carbonic anhydrase 5A, mitochondrial
Synonyms:
CAH5A_MOUSE | Ca5 | Ca5a | Car5 | Car5a | Carbonate dehydratase VA | Carbonic Anhydrase V | Carbonic Anhydrase VA | Carbonic anhydrase 5A, mitochondrial precursor
Type:
Enzyme
Mol. Mass.:
34081.17
Organism:
Mus musculus (mouse)
Description:
Full length murine, cloned isozyme.
Residue:
299
Sequence:
MLRRDPRKPLAILRHVGLLCATGPQRWRFQHSCAEEHSNCARHPLWTGPVSSAEGTRQSPINIQWKDSVYDPQLAPLRVSYDAASCRYLWNTGYFFQVEFDDSCEDSGISGGPLGNHYRLKQFHFHWGATDEWGSEHAVDGHTYPAELHLVHWNSTKYENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEVRHKDTQVAMGPFDPSCLLPACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSTFRTLLFSGRGEEEDVMVNNYRPLQPLRDRKLRSSFRLDRTKMRS
  
Inhibitor
Name:
BDBM16649
Synonyms:
2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | 4-Pivaloylamido-benzenesulfonamide | CHEMBL23285 | aromatic sulfonamide compound 14
Type:
Small organic molecule
Emp. Form.:
C11H16N2O3S
Mol. Mass.:
256.321
SMILES:
CC(C)(C)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Structure:
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Substrate
Name:
BDBM10856
Synonyms:
Carbon Dioxide | methanedione
Type:
Small organic molecule
Emp. Form.:
CO2
Mol. Mass.:
44.0095
SMILES:
O=C=O
Structure:
Search PDB for entries with ligand similarity: