Reaction Details Report a problem with these data
Target
Homoisocitrate dehydrogenase
Ligand
BDBM23221
Substrate
BDBM23214
Meas. Tech.
Enzyme Inhibition Assay
pH
7.8±n/a
Temperature
301.15±n/a K
Ki
88000±n/a nM
Km
211000±n/a nM
kcat
46±n/a 1/sec
Citation
Yamamoto, T; Miyazaki, K; Eguchi, T Substrate specificity analysis and inhibitor design of homoisocitrate dehydrogenase. Bioorg Med Chem 15:1346-55 (2007) [PubMed] Article
More Info.:
Target
Name:
Homoisocitrate dehydrogenase
Synonyms:
DraHICDH | Homoisocitrate Dehydrogenase (HICDH) | Isocitrate dehydrogenase
Type:
Enzyme
Mol. Mass.:
35741.95
Organism:
Deinococcus radiodurans
Description:
Q76G12
Residue:
332
Sequence:
MAKYRICLIEGDGIGHEVIPAAKRVLEAAGFDAEYVHAEAGYEYFLDHGTSVPEATYDAVENTDATLFGAATSPSGEKPAGFFGAIRHLRQKYNLYANVRPTKTRPVPHSYENVDLVIVRENTQGLYVEQERRYGDTAIADTVITREASDRIGKFAADLAMKRSKRLTVVHKSNVLPVTQGLFMNTILDHTKTVEGLSTSTMIVDNAAMQLVRNPQQFDVMVMTNMFGDILSDLAAGLVGGLGIAASGNVGDQFGIFESVHGSAPDIAGQGISNPTATILAAVIMLDHLGDHETARRLDNAINKVLAEPRTRDLGGTAGTQEFTEAVIKALA
Inhibitor
Name:
BDBM23221
Synonyms:
(2S,3R)-2-ethenyl-3-hydroxybutanedioic acid | Vinylmalate, 19
Type:
Small organic molecule
Emp. Form.:
C6H8O5
Mol. Mass.:
160.1247
SMILES:
[H][C@](O)(C(O)=O)[C@]([H])(C=C)C(O)=O |r|