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Target
Regulator of G-protein signaling 7
Ligand
BDBM47693
Substrate
n/a
Meas. Tech.
Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao. PubChem Bioassay (2009)[AID]
Target
Name:
Regulator of G-protein signaling 7
Synonyms:
RGS7 | RGS7_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57675.72
Organism:
Homo sapiens (Human)
Description:
P49802
Residue:
495
Sequence:
MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPCHKNCTPTLRASTNLL
  
Inhibitor
Name:
BDBM47693
Synonyms:
1-[3-(2-Chloro-6-fluoro-benzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]-piperidin-4-ol | 1-[3-(2-chloro-6-fluoro-benzyl)triazolo[4,5-d]pyrimidin-7-yl]piperidin-4-ol | 1-[3-[(2-chloranyl-6-fluoranyl-phenyl)methyl]-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl]piperidin-4-ol | 1-[3-[(2-chloro-6-fluorophenyl)methyl]-7-triazolo[4,5-d]pyrimidinyl]-4-piperidinol | 1-[3-[(2-chloro-6-fluorophenyl)methyl]triazolo[4,5-d]pyrimidin-7-yl]piperidin-4-ol | MLS000075681 | SMR000000498 | cid_644683
Type:
Small organic molecule
Emp. Form.:
C16H16ClFN6O
Mol. Mass.:
362.789
SMILES:
OC1CCN(CC1)c1ncnc2n(Cc3c(F)cccc3Cl)nnc12
Structure:
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