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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM73157
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
17900±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID]
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM73157
Synonyms:
4-(carbamoylamino)benzoic acid [2-(2-methoxyanilino)-2-oxoethyl] ester | 4-ureidobenzoic acid [2-keto-2-(o-anisidino)ethyl] ester | MLS-0435524.0001 | [2-(2-methoxyanilino)-2-oxoethyl] 4-(carbamoylamino)benzoate | [2-[(2-methoxyphenyl)amino]-2-oxidanylidene-ethyl] 4-(aminocarbonylamino)benzoate | cid_2115738
Type:
Small organic molecule
Emp. Form.:
C17H17N3O5
Mol. Mass.:
343.334
SMILES:
COc1ccccc1NC(=O)COC(=O)c1ccc(NC(N)=O)cc1
Structure:
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