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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM73169
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
>100000±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID]
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM73169
Synonyms:
4-hydroxy-N-[[3-methoxy-4-[2-(3-nitroanilino)-2-oxoethoxy]phenyl]methylideneamino]benzamide | 4-hydroxy-N-[[4-[2-keto-2-(3-nitroanilino)ethoxy]-3-methoxy-benzylidene]amino]benzamide | MLS-0347266.0001 | N-[[3-methoxy-4-[2-[(3-nitrophenyl)amino]-2-oxidanylidene-ethoxy]phenyl]methylideneamino]-4-oxidanyl-benzamide | cid_3115909
Type:
Small organic molecule
Emp. Form.:
C23H20N4O7
Mol. Mass.:
464.4275
SMILES:
COc1cc([CH+][N-]NC(=O)c2ccc(O)cc2)ccc1OCC(=O)Nc1cccc(c1)[N+]([O-])=O
Structure:
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