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Target
Short transient receptor potential channel 3
Ligand
BDBM50239162
Substrate
n/a
Meas. Tech.
ChEMBL_1665388 (CHEMBL4015184)
EC50
236±n/a nM
Citation
 Qu, C; Ding, M; Zhu, Y; Lu, Y; Du, J; Miller, M; Tian, J; Zhu, J; Xu, J; Wen, M; Er-Bu, A; Wang, J; Xiao, Y; Wu, M; McManus, OB; Li, M; Wu, J; Luo, HR; Cao, Z; Shen, B; Wang, H; Zhu, MX; Hong, X Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels. J Med Chem 60:4680-4692 (2017) [PubMed]  Article
Target
Name:
Short transient receptor potential channel 3
Synonyms:
TRP-3 | TRP3 | TRPC3 | TRPC3_HUMAN | Transient receptor protein 3 | hTrp-3 | hTrp3
Type:
PROTEIN
Mol. Mass.:
96009.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107641
Residue:
836
Sequence:
MREKGRRQAVRGPAFMFNDRGTSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSMLRCE
  
Inhibitor
Name:
BDBM50239162
Synonyms:
CHEMBL4060400
Type:
Small organic molecule
Emp. Form.:
C26H25FN4O3
Mol. Mass.:
460.5001
SMILES:
Cc1nn2c(O)cc(nc2c1-c1ccc(F)cc1)C1CCN(CC1)C(=O)OCc1ccccc1
Structure:
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