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Target
STAM-binding protein
Ligand
BDBM50264422
Substrate
n/a
Meas. Tech.
ChEMBL_1698729 (CHEMBL4049711)
IC50
6800±n/a nM
Citation
 Perez, C; Li, J; Parlati, F; Rouffet, M; Ma, Y; Mackinnon, AL; Chou, TF; Deshaies, RJ; Cohen, SM Discovery of an Inhibitor of the Proteasome Subunit Rpn11. J Med Chem 60:1343-1361 (2017) [PubMed]  Article
Target
Name:
STAM-binding protein
Synonyms:
AMSH | STABP_HUMAN | STAM-binding protein (AMSH) | STAMBP
Type:
Protein
Mol. Mass.:
48073.82
Organism:
Homo sapiens (Human)
Description:
O95630
Residue:
424
Sequence:
MSDHGDVSLPPEDRVRALSQLGSAVEVNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAFILYNKYITLFIEKLPKHRDYKSAVIPEKKDTVKKLKEIAFPKAEELKAELLKRYTKEYTEYNEEKKKEAEELARNMAIQQELEKEKQRVAQQKQQQLEQEQFHAFEEMIRNQELEKERLKIVQEFGKVDPGLGGPLVPDLEKPSLDVFPTLTVSSIQPSDCHTTVRPAKPPVVDRSLKPGALSNSESIPTIDGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFTITHVLIPKQSAGSDYCNTENEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESVAIVCSPKFQETGFFKLTDHGLEEISSCRQKGFHPHSKDPPLFCSCSHVTVVDRAVTITDLR
  
Inhibitor
Name:
BDBM50264422
Synonyms:
CHEMBL4091693
Type:
Small organic molecule
Emp. Form.:
C30H30N4O4S2
Mol. Mass.:
574.714
SMILES:
O=C(NCC1CCCO1)c1cnc2c(SSc3cccc4cc(cnc34)C(=O)NCC3CCCO3)cccc2c1
Structure:
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