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Target
Metabotropic glutamate receptor 7
Ligand
BDBM50283488
Substrate
n/a
Meas. Tech.
ChEMBL_1725548 (CHEMBL4140826)
EC50
1047±n/a nM
Citation
 Abe, M; Seto, M; Gogliotti, RG; Loch, MT; Bollinger, KA; Chang, S; Engelberg, EM; Luscombe, VB; Harp, JM; Bubser, M; Engers, DW; Jones, CK; Rodriguez, AL; Blobaum, AL; Conn, PJ; Niswender, CM; Lindsley, CW Discovery of VU6005649, a CNS Penetrant mGlu ACS Med Chem Lett 8:1110-1115 (2017) [PubMed]  Article
Target
Name:
Metabotropic glutamate receptor 7
Synonyms:
GRM7_RAT | Gprc1g | Grm7 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 7 (mGlu7) | Mglur7 | mGlu7
Type:
Enzyme
Mol. Mass.:
102244.48
Organism:
Rattus norvegicus (Rat)
Description:
P35400
Residue:
915
Sequence:
MVQLGKLLRVLTLMKFPCCVLEVLLCVLAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRHVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPSSVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQNIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
  
Inhibitor
Name:
BDBM50283488
Synonyms:
CHEMBL4171274
Type:
Small organic molecule
Emp. Form.:
C17H14F5N3O
Mol. Mass.:
371.3046
SMILES:
CCc1nn2c(cc(C)nc2c1-c1ccc(OC)c(F)c1F)C(F)(F)F |(39.73,-48.22,;38.96,-49.56,;37.42,-49.57,;36.52,-48.33,;35.06,-48.81,;33.73,-48.04,;32.4,-48.81,;32.4,-50.35,;31.07,-51.12,;33.73,-51.12,;35.07,-50.34,;36.53,-50.81,;37.01,-52.27,;35.98,-53.42,;36.47,-54.88,;37.98,-55.19,;38.46,-56.65,;37.44,-57.81,;39,-54.04,;40.51,-54.34,;38.52,-52.58,;39.54,-51.43,;33.73,-46.5,;35.07,-45.72,;32.4,-45.72,;33.72,-44.96,)|
Structure:
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