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Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM29589
Substrate
n/a
Meas. Tech.
ChEMBL_1779304 (CHEMBL4236296)
Ki
>10000±n/a nM
Citation
 Fournier, JF; Bhurruth-Alcor, Y; Musicki, B; Aubert, J; Aurelly, M; Bouix-Peter, C; Bouquet, K; Chantalat, L; Delorme, M; Drean, B; Duvert, G; Fleury-Bregeot, N; Gauthier, B; Grisendi, K; Harris, CS; Hennequin, LF; Isabet, T; Joly, F; Lafitte, G; Millois, C; Morgentin, R; Pascau, J; Piwnica, D; Rival, Y; Soulet, C; Thoreau, É; Tomas, L Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma. Bioorg Med Chem Lett 28:2985-2992 (2018) [PubMed]  Article
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM29589
Synonyms:
Faridak | LBH-589 | LBH-589B | Panobinostat | US10722597, Compound Panobinostat
Type:
Small organic molecule
Emp. Form.:
C21H23N3O2
Mol. Mass.:
349.4262
SMILES:
Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1
Structure:
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