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Target
Myotonin-protein kinase
Ligand
BDBM50465950
Substrate
n/a
Meas. Tech.
ChEMBL_1789430 (CHEMBL4261164)
IC50
>1000±n/a nM
Citation
 Verga, D; N'Guyen, CH; Dakir, M; Coll, JL; Teulade-Fichou, MP; Molla, A Polyheteroaryl Oxazole/Pyridine-Based Compounds Selected in Vitro as G-Quadruplex Ligands Inhibit Rock Kinase and Exhibit Antiproliferative Activity. J Med Chem 61:10502-10518 (2018) [PubMed]  Article
Target
Name:
Myotonin-protein kinase
Synonyms:
DM1PK | DMPK | DMPK_HUMAN | MDPK
Type:
Enzyme Catalytic Domain
Mol. Mass.:
69359.66
Organism:
Homo sapiens (Human)
Description:
gi_47059024
Residue:
629
Sequence:
MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPFTPDFEGATDTCNFDLVEDGLTAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEAEQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARVPRPGLSEALSLLLFAVVLSRAAALGCIGLVAHAGQLTAVWRRPGAARAP
  
Inhibitor
Name:
BDBM50465950
Synonyms:
CHEMBL4284998
Type:
Small organic molecule
Emp. Form.:
C27H15N7O4
Mol. Mass.:
501.4525
SMILES:
c1ncc(o1)-c1ccc(nc1)-c1cnc(o1)-c1cccc(n1)-c1ncc(o1)-c1ccc(cn1)-c1cnco1
Structure:
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