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Target
DNA gyrase subunit A
Ligand
BDBM50478004
Substrate
n/a
Meas. Tech.
ChEMBL_464479 (CHEMBL948210)
IC50
109000±n/a nM
Citation
 Dinakaran, M; Senthilkumar, P; Yogeeswari, P; China, A; Nagaraja, V; Sriram, D Novel ofloxacin derivatives: synthesis, antimycobacterial and toxicological evaluation. Bioorg Med Chem Lett 18:1229-36 (2008) [PubMed]  Article
Target
Name:
DNA gyrase subunit A
Synonyms:
5.6.2.2 | DNA gyrase subunit A | GYRA_MYCSM | gyrA
Type:
PROTEIN
Mol. Mass.:
94927.62
Organism:
Mycobacterium smegmatis
Description:
ChEMBL_102869
Residue:
854
Sequence:
MTDTTLPPEGEAHDRIEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMYDSASSDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSRGIAVGMATNNPPHNLGELAEAVYWCLENYEADEEATCEAVMERVKGPDFPTSGLIVGTQGIEDTYKTGRGSIKMRGVVEIEEDSRGRTSIVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVVELKRDAVAKVVLNNLYKHTQLQTSFGANMLSIVDGVPRTLRLDQLIRLYVDHQLDVIVRRTRYRLRKANERAHILRGLVKALDALDEVIALIRASQTVDIARAGLIELLDIDDIQAQAILDMQLRRLAALERQKIVDDLAKIEAEIADLEDILAKPERQRGIVRDELKEIVDKHGDARRTRIVPADGQVSDEDLIAREDVVVTITETGYAKRTKTDLYHSQKRGGKGVQGAGLKQDDMVNHFFVCSTHDWILFFTTQGRVYRAKAYELPEASRTARGQHVANLLAFQPEERIAQVIQIKSYEDAPYLVLATRNGLVKKSKLSDFDSNRSGGIVAINLREGDELVGAVLCSAEDDLLLVSANRQSIRFSATDEALRPMGRATSGVQGMRFNEDDRLLSLNVVRPDTYLLVATSGGYAKRTSIDEYSVQGRGGKGILTIQYDRKRGSLVGALIVDDDTELYAITSTGGVIRTAARQVRKAGRQTKGVRLMNLAEGDTLIAIARNGRGRGGRVDQRIRRGHRRVTRGVMETLRSRKVLGPS
  
Inhibitor
Name:
BDBM50478004
Synonyms:
CHEMBL405342
Type:
Small organic molecule
Emp. Form.:
C17H17FN2O4S
Mol. Mass.:
364.391
SMILES:
CC1COc2c(N3CCSCC3)c(F)cc3c2n1cc(C(O)=O)c3=O
Structure:
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