Reaction Details  Report a problem with these data
Target
Phenylalanine-4-hydroxylase
Ligand
BDBM50028427
Substrate
n/a
Meas. Tech.
ChEBML_154856
Ki
125000±n/a nM
Citation
 Henrie, RN; Lazarus, RA; Benkovic, SJ Preparation of 2-amino-4(3H)-oxopyrimido[5,4-b] [1,4]thiazines (5-thiapterins) and their evaluation as cofactors for phenylalanine hydroxylase. J Med Chem 26:559-63 (1983) [PubMed]
Target
Name:
Phenylalanine-4-hydroxylase
Synonyms:
PH4H_RAT | Pah | Phe-4-monooxygenase
Type:
PROTEIN
Mol. Mass.:
51817.61
Organism:
Rattus norvegicus
Description:
ChEMBL_154856
Residue:
453
Sequence:
MAAVVLENGVLSRKLSDFGQETSYIEDNSNQNGAISLIFSLKEEVGALAKVLRLFEENDINLTHIESRPSRLNKDEYEFFTYLDKRTKPVLGSIIKSLRNDIGATVHELSRDKEKNTVPWFPRTIQELDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYTEEEKQTWGTVFRTLKALYKTHACYEHNHIFPLLEKYCGFREDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKEGDSIKAYGAGLLSSFGELQYCLSDKPKLLPLELEKTACQEYSVTEFQPLYYVAESFSDAKEKVRTFAATIPRPFSVRYDPYTQRVEVLDNTQQLKILADSINSEVGILCNALQKIKS
  
Inhibitor
Name:
BDBM50028427
Synonyms:
2-Amino-6-methyl-5-oxo-5,6,7,8-tetrahydro-3H-5lambda*4*-pyrimido[5,4-b][1,4]thiazin-4-one | CHEMBL345752
Type:
Small organic molecule
Emp. Form.:
C7H8N4O2S
Mol. Mass.:
212.229
SMILES:
CC1=CNc2nc(N)[nH]c(=O)c2S1=O |t:1|
Structure:
Search PDB for entries with ligand similarity: