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Target
DNA-binding transcriptional activator DevR/DosR
Ligand
BDBM50480869
Substrate
n/a
Meas. Tech.
ChEMBL_591894 (CHEMBL1045964)
IC50
258000±n/a nM
Citation
 Gupta, RK; Thakur, TS; Desiraju, GR; Tyagi, JS Structure-based design of DevR inhibitor active against nonreplicating Mycobacterium tuberculosis. J Med Chem 52:6324-34 (2009) [PubMed]  Article
Target
Name:
DNA-binding transcriptional activator DevR/DosR
Synonyms:
DEVR_MYCTU | DNA-binding transcriptional activator DevR/DosR | devR | dosR
Type:
PROTEIN
Mol. Mass.:
23292.23
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
ChEMBL_102872
Residue:
217
Sequence:
MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAEAMARVPAARPDVAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAILAGASGYVVKDIKGMELARAVKDVGAGRSLLDNRAAAALMAKLRGAAEKQDPLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEKTVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP
  
Inhibitor
Name:
BDBM50480869
Synonyms:
CHEMBL583462
Type:
Small organic molecule
Emp. Form.:
C21H19FN2O4
Mol. Mass.:
382.385
SMILES:
CCOc1cc(\C=C2/NC(=O)N(C2=O)c2ccccc2F)cc(CC=C)c1O
Structure:
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