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Target
Ryanodine receptor
Ligand
BDBM50222771
Substrate
n/a
Meas. Tech.
ChEMBL_923838 (CHEMBL3073771)
IC50
2.0±n/a nM
Citation
 Jeanguenat, A The story of a new insecticidal chemistry class: the diamides. Pest Manag Sci 69:7-14 (2013) [PubMed]  Article
Target
Name:
Ryanodine receptor
Synonyms:
Ryanodine receptor
Type:
PROTEIN
Mol. Mass.:
580726.80
Organism:
Bemisia tabaci
Description:
ChEMBL_106584
Residue:
5142
Sequence:
MTKMTEADGGSEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDLSQCVLVIEQPPSVRALQELVTAAGSEQGHRRAKNKVIPLNLFKPGKGTGSGHRTLLYGNAILLRHQNSDMYLACLSTSSSNDKLSFDVGLQEHSQGEACWWTVHPASKQRSEGEKVRVGDDLILVSVATERYLHTAKENDLSVVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPSNWTETTGQNIVIYEGGSVMSQARSLWRLELARTKWAGAFINWYHPMRIRHLTTGRYLSVNENNELHLVGRDEATTATSTFCLRQEKDDQKVVLEDKDLEVIGAPIIKYGDSTVLVQHSETGLWLTYKSYEAKKKGVGKVEEKQAVLHEEGKMDDGLDFSRSQEEESRTARVIRKCSHLFTQFIKGLETLQSNRRQSVFTSSVNLNEMVMCLEDLINYFAQPEEDMEHEEKQNKLRALRNRQDLFQEEGILNLILEAIDKINVITSQGLMVNLGGDESGQCWEVISGYLYQLLAAIIRGNHTNCAQFANSNRLNWLFSRLGSQASSEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISLLEKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDFLLPGKNLLLQTQLVDHVASVRPNIFVGRVEGSAVYQKWYFEVTLDHIEKTTHMTPHLRIGWANTAGYVPYPGGGEKWGGNGVGDDLYSFGYDGANLWTGGKFTNVAEAAEPFIKKGDVIGCALDLTIPVITFSFNGQPVQGHFRDFNLDGMFFPVISCSSKLSCRFLLGGDHGRLKYVPPKEFSPLVESLLPQQILSIDPCFYFGNLNKCTLAGPWPVEDDTAFVPAPVDTSMINLPSYIESIRDRLAENIHEMWALNKIEAGWQYGEVRDDIRKIHPCLVQFDRLPPAEKRYDSQLAVQTLKTILALGYHITMDKPSSRIKTIRLPNEPFMQSNGYKPAPLDLAAITLNVKMEELVDQLAENTHNLWAKERIQQGWTYGLNEDPDMLRSPHLVPYPKVDDAIKKANRDTASETVRTLLVYGYMLDPPTGDPNEAALLAEANRLRQMAFRTYRVEKNYAVSSGKWYFEFEVLTTGPMRVGWARVDCSPGHQLGSDENSWAFDGFNSVKIHMGSTELFGHQYKVGDIVGCFLDLCDSTISFSLNGEPLMDALGGETTFSDVQGDAFVPAFTLGVGQRAKLTFGQDVNLLKFFTVCGLQEGYEPFCVNMNRAVTYWHTKDQPIFENTDDYASPFDVTRIPAGSDTPPCLKISHNTFETMEKANWEFLRLSLPIICLPEFIDEAEKMRRWQEIRIRQHRLLAEADKTTPAHIEQIMKSGFSMSDIKGLHRGYSEDAVEADEMMNGGGAGPIQSKSKKSPARPPRKGSLSRNEDLQMDSIMPSGKIHRSSSELDVNRYSNMNGNADLKDDKKKRGRSPFRFFSRKRDQSGERGKKAKTPEPGGMVAERFEGLGQGRTGQQFRTSQANIKLVPPAIPDRNPTGPKQMSGSPLTSSGVEAIGNEIYDVECLKMMNEYFYAVRIFPGQDPTHVYIGWVTTQYHLHSSTFNQSHVRQSNITVLDDYGRIVDNINRQSCYMLRADELYNEVTNDASGKGASQGMTIGCFIDTATGIMSFTCEGKETSHKFKMEPEAKLFPAIFVEATSKKVLQIELGRTSTTLPLSSAILQNSERHVTPQFPPRLKVQCLRPHQWARVPNISLQVHALKLSDVRGWSMLCEDPVSMLALHIPEEDRCIDILELIEMEKLLSFHAHTLTLYAALCYQANYRAAHTLCQHVDQKQLLYAIRSEYMSGPLRQGFYDLLIALHLDPHAMTMEACKNEYIIPLGQELKVLYEDPQMGHSLRSLATESVQPLMKMTDIAETVDNIRSLYSPYFPLDVVRDFVMTALDEAVQINQVHNRDPVGGSNENLFLPLLKLVDRLMLVGVLRDEDVMKLLIMFNPETWDPLFEKDGKDEHRKGLLNMKMAEGAKLQMCYLLHHLCDLQLRHRVESIIAFSHDFVGELQSDQLRRYIDIKQSDLPSAIAAKKTKEFRCPPREQMNAVLGFKNLEEDDHENCPCGDELRERMNEFHTSVMRHVSLLALQEPSEEEEKTDGVAKPNVFKRLTNFINAVKELEEEPKPPEEPEKKSPEEIFRKVLISTIVKWAEESQIEMPKLVREMFSLLVRQYDSVGELVRALEKTYVINNKTKGDAAGMWVGLSQIRSLLPVQMSQEEEELMRERLWKLVNNHTFFQHPDLIRILRVHENVMAIMINTLGRRAQAQSDAPQVGTGALDGEPVAKEKDTSHEMVVACCRFLCYFCRTSRQNQKAMFDHLSFLLENSNILLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAIYLSRCGLQSNSELIEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECLGPALRGEGEGLLRAIMDANKMSEQIADRRKLMDEAEGSTAVMQFEHPLPESDEDEDYIDTGAAILNFYCTLVDLLGRCAPDASVIAQGKNESLRARAILRSLVPLEDLLGVLSLRFTLQNPAAGEERPKSDMPSGLIPGHKQSVVLFLERVYGIEQQDLFFKILEEAFLPDLRAATMLDRNDGLESEMALAMNRYIGNSILPLLISHSRFYNESDNYANLLDATLHTVYRLSKNRMLTKGQREAVSDFLVALTSQMQPSMLLKLLRKLTVDVSTLSEYTTVALRLLTLHYDRCAKYYGSSGGQGLYGASSEEEKRLTMMLFSNIFDSLSKMDYDPELFGKALPCLIAIGCALPPDYSLSKNYDDEWYGSKTQVQTGPADGPYNPQPINTSSVQLNNDLNTIVQKFSEHYHDAWANRKLENGWVYGEQYSDSQKVHPRLKPYAMLNDYEEKERYKEPVRESLKALLAIGWTVEHTEVDVPISNRNSVRRQSKATLDTATPFNYHPNPIDMTNLTLSREMQNMAERLAENAHDIWAKKKKEELVTCGGGIHPQLVPYDLLTDKEKRKDRERSQEFLKYLQYQGYKLHRPNRGTATSEAEQLAAVQTGELRFAYSLLEKLIQYMDKASINMKLLKPSATFSRRSSFKTCSRDIKFFSKVVLPLVEKYFNSHRNYFIVVATASNNVGAASLKEKEMVASLFCKLASLLRSRLAAFGADVRITVRCLQTLVKSIDARSLVKNCPEFIRTSMLTFFNNTADDLGHTIINLQEGKYSHLRGTHLKTSTSLFYVNDVILPVLTAMFDHLAACEYGSDLLLDEIQVASYKILSSLFTLGIDSSLTHDRKYLKTEIERHRPALGTCLGAFSSTFPVAFLEPHLNKHNQFSLLNRIADHSLEAQDIMARMESSMPTLEAVLGEVDQFVESGKSHSDAPHVIDVILPLLCSYLPVWWAQGPDNVNLTAGNHVTMVTSDHMNQLLKNVLNMIKKNISNDNAPWMTRIAAYTQQIIINSSEELLKDPFLPLAERVKRRTENLFHKEESLRGFIKSATDDTSQVETQIQEDWSLVVRDIYAFYPLLIKYVDLQRNHWLRNNIPEAEDLYNHISEIFNIWSKSQYFLREEQNFISANEIDNMILIMPTATRRSASAVSEGTGSGGRGKKKKKHRDKKRDKDKELQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRFLKKMQEYEIMDFVKTQLTLPDKIDPADEMSWQHYLYSKLGSKKDGGEVAKPQQIDEVVDRIVAMAKVLYGLHMIDHPQLQSKAVYRSVVSTQRKRAVIACFRQLSLHALPRHRAVNIFGRTYRELWLQDENVGQEVMIEDLTQSFEEAELKKQDKEENEGKPDPLTQLVTTFCRGAMTERSGALQEDPLYMSYAEIIAKSCGEEEEEGGEEEGEEAAEGEEGGTSIHEQEMEKQKLLFNQSRLADRGVAEMVLLHISACKGVPSEMVMKTLQLGIAVLRGGNSDIQMGMLNHLKEKKDVGFFTSIAGLMNSCSVLDLDAFERNTKAEGLGVGLEGAAGEKNMHDAEFTCTLFRFIQLTCEGHNLEWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKELIDPAGKANFFKAIGVASQVFNTLSEVIQGPCTQNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHSSQVDLLKELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESASNVELILKYFDMFLKLKDLTSSASFLEIDPNNEGWVLPKDFKEKMEQQKSYTPEEIEFMLACCETNHDGKIDYVGFTDRFHEPAKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEPFLGRIEILGGSKKIERVYFEIKESNIEQWEKPQIKESKRAFFYSIVTEGGDKEKLEAFVNFCEDAIFEMQHASGLMAVDDGSGVGGGKTRKAAYSYLSDEDEEKNVHPIKRGLQAVKDTVFFLFAMLSPSNIKQKLGELQQMSVPEMVIGFFKLIFYLFYYSGFSVMVVFRYFGRILMSLVRGPQVEEPVVEIKEEEKWGSMRKLPALPPPEDGKDSQLIMRGSEGSKEDGAHIKPSGHEDTPMSAQLGTEEGGDSPTGESGDSHSKSDSDEGFRAEGALTLTEFLGGGAAKKEAALVAEVAAQHQAVMAAVEAEGKQETVSEPSAVSQIDFNGYTHRALSFLARNFYNLKYAALVLAFCINFILLFYKVTVIGGEEEDGGSGDDFGGLSGEDLLGSVGLDAGSGEDGGGSGGSGEDEEEPLEIVHVDEDFFYMYHILRFAAFLHSLVSLAMLIAYYHLKAPLAIFKREKEIARRLEFDGLFIAEQPSDDDIKSHWDKLVISAKSFPVNYWDKFAKKKVRQKYSETYDFDSISNLLGMEKTSFSSQENEEGSGIVYFILNIDWRYQIWKAGVTITDNAFLYSLWYFTFSILGNFNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTIIVYIYTVIAFNFFRKFYAQEEDDNVDMKCHNMLTCFVFHLYKGVRAGGGIGDEIEPPDGDDYEVYRIMFDITFFFFVIVILLAIIQGLIIDAFGELRDQLESVKDDMESNCFICGIGKDFFDTVPHGFDTHVQQEHNLANYMFFLMHLINKPDTEYTGQETYVWNMYQQRCWDFFPVGDCFRKQYEEELGGGGG
  
Inhibitor
Name:
BDBM50222771
Synonyms:
3-bromo-N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide | CHEMBL399318 | Chlorantraniliprole
Type:
Small organic molecule
Emp. Form.:
C18H14BrCl2N5O2
Mol. Mass.:
483.146
SMILES:
CNC(=O)c1cc(Cl)cc(C)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl
Structure:
Search PDB for entries with ligand similarity: