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Target
UDP-glucuronosyltransferase 1A1
Ligand
BDBM50508419
Substrate
n/a
Meas. Tech.
ChEMBL_1833056 (CHEMBL4333064)
IC50
>50000±n/a nM
Citation
 Lee, D; Pagire, HS; Pagire, SH; Bae, EJ; Dighe, M; Kim, M; Lee, KM; Jang, YK; Jaladi, AK; Jung, KY; Yoo, EK; Gim, HE; Lee, S; Choi, WI; Chi, YI; Song, JS; Bae, MA; Jeon, YH; Lee, GH; Liu, KH; Lee, T; Park, S; Jeon, JH; Lee, IK; Ahn, JH Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases. J Med Chem 62:575-588 (2019) [PubMed]  Article
Target
Name:
UDP-glucuronosyltransferase 1A1
Synonyms:
Bilirubin-specific UDPGT isozyme 1 | GNT1 | UD11_HUMAN | UDP-glucuronosyltransferase 1-1 | UDP-glucuronosyltransferase 1-A | UDP-glucuronosyltransferase 1A1 | UDPGT 1-1 | UGT-1A | UGT1 | UGT1*1 | UGT1-01 | UGT1.1 | UGT1A | UGT1A1 | Uridine-5'-diphosphoglucuronosyltransferase 1A1 | hUG-BR1
Type:
Enzyme
Mol. Mass.:
59604.34
Organism:
Homo sapiens (Human)
Description:
P22309
Residue:
533
Sequence:
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQREVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
  
Inhibitor
Name:
BDBM50508419
Synonyms:
CHEMBL4471264
Type:
Small organic molecule
Emp. Form.:
C22H20ClN3O2
Mol. Mass.:
393.866
SMILES:
Cl.O=C1c2ccccc2C(=O)c2c(cccc12)-c1cnn(c1)C1CCNCC1
Structure:
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