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Target
Taste receptor type 2 member 8
Ligand
BDBM211358
Substrate
n/a
Meas. Tech.
ChEMBL_1845977 (CHEMBL4346404)
IC50
40±n/a nM
Citation
 Fotsing, JR; Darmohusodo, V; Patron, AP; Ching, BW; Brady, T; Arellano, M; Chen, Q; Davis, TJ; Liu, H; Servant, G; Zhang, L; Williams, M; Saganich, M; Ditschun, T; Tachdjian, C; Karanewsky, DS Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists. J Med Chem 63:4957-4977 (2020) [PubMed]  Article
Target
Name:
Taste receptor type 2 member 8
Synonyms:
T2R8 | TA2R8_HUMAN | TAS2R8 | TRB5 | Taste receptor family B member 5 | Taste receptor type 2 member 8 (T2R8)
Type:
n/a
Mol. Mass.:
35897.08
Organism:
Homo sapiens (Human)
Description:
Q9NYW2
Residue:
309
Sequence:
MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLISVMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFLWLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYFEPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSFIFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRMLTCRKIACMI
  
Inhibitor
Name:
BDBM211358
Synonyms:
US9247759, 12-9
Type:
Small organic molecule
Emp. Form.:
C20H21N5O5
Mol. Mass.:
411.4112
SMILES:
Cc1noc(C)c1Cn1cc(cn1)N1C(=O)[C@H](CO)N(Cc2cccc(O)c2)C1=O |r|
Structure:
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