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Target
Urea transporter 1
Ligand
BDBM50512227
Substrate
n/a
Meas. Tech.
ChEMBL_1848171 (CHEMBL4348712)
IC50
1720±n/a nM
Citation
 Zhao, Y; Li, M; Li, B; Zhang, S; Su, A; Xing, Y; Ge, Z; Li, R; Yang, B Discovery and optimization of thienopyridine derivatives as novel urea transporter inhibitors. Eur J Med Chem 172:131-142 (2019) [PubMed]  Article
Target
Name:
Urea transporter 1
Synonyms:
HUT11 | JK | RACH1 | SLC14A1 | Solute carrier family 14 member 1 | UT1 | UT1_HUMAN | UTE | Urea transporter, erythrocyte
Type:
PROTEIN
Mol. Mass.:
42529.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107607
Residue:
389
Sequence:
MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPFNMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQAKKRMVESPL
  
Inhibitor
Name:
BDBM50512227
Synonyms:
CHEMBL4454312
Type:
Small organic molecule
Emp. Form.:
C14H12N2OS
Mol. Mass.:
256.323
SMILES:
CC(=O)c1sc2nc3ccc(C)cc3cc2c1N
Structure:
Search PDB for entries with ligand similarity: