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Target
Lactoylglutathione lyase
Ligand
BDBM50517462
Substrate
n/a
Meas. Tech.
ChEMBL_1869127 (CHEMBL4370193)
IC50
1210±n/a nM
Citation
 Perez, C; Barkley-Levenson, AM; Dick, BL; Glatt, PF; Martinez, Y; Siegel, D; Momper, JD; Palmer, AA; Cohen, SM Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor. J Med Chem 62:1609-1625 (2019) [PubMed]  Article
Target
Name:
Lactoylglutathione lyase
Synonyms:
Aldoketomutase | GLO1 | Glx I | Glyoxalase 1 (GLO1) | Glyoxalase I | Ketone-aldehyde mutase | LGUL_HUMAN | Methylglyoxalase | S-D-lactoylglutathione methylglyoxal lyase
Type:
Enzyme
Mol. Mass.:
20772.95
Organism:
Homo sapiens (Human)
Description:
Q04760
Residue:
184
Sequence:
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKMATLM
  
Inhibitor
Name:
BDBM50517462
Synonyms:
CHEMBL4467660
Type:
Small organic molecule
Emp. Form.:
C22H19N3O2S
Mol. Mass.:
389.47
SMILES:
O=S(=O)(Nc1cc(CCc2ccccc2)cc2cccnc12)c1ccccn1
Structure:
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