Reaction Details  Report a problem with these data
Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50517924
Substrate
n/a
Meas. Tech.
ChEMBL_1870043 (CHEMBL4371210)
IC50
60±n/a nM
Citation
 Smolinski, MP; Bu, Y; Clements, J; Gelman, IH; Hegab, T; Cutler, DL; Fang, JWS; Fetterly, G; Kwan, R; Barnett, A; Lau, JYN; Hangauer, DG Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361). J Med Chem 61:4704-4719 (2018) [PubMed]  Article
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Neuronal proto-oncogene tyrosine-protein kinase Src | Proto-oncogene c-Src | SRC_MOUSE | Src | Tyrosine-protein kinase SRC | pp60c-src (p60-Src)
Type:
Protein
Mol. Mass.:
59894.66
Organism:
Mus musculus (Mouse)
Description:
P05480
Residue:
535
Sequence:
MGSNKSKPKDASQRRRSLEPSENVHGAGGAFPASQTPSKPASADGHRGPSAAFVPPAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50517924
Synonyms:
KX-02 | KX-2361 | Kx2-361
Type:
Small organic molecule
Emp. Form.:
C24H24FN3O2
Mol. Mass.:
405.4647
SMILES:
Fc1cccc(CNC(=O)Cc2ccc(cn2)-c2ccc(cc2)N2CCOCC2)c1
Structure:
Search PDB for entries with ligand similarity: