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Target
Decaprenylphosphoryl-beta-D-ribose oxidase
Ligand
BDBM50517942
Substrate
n/a
Meas. Tech.
ChEMBL_1870171 (CHEMBL4371338)
IC50
60±n/a nM
Citation
 Chikhale, RV; Barmade, MA; Murumkar, PR; Yadav, MR Overview of the Development of DprE1 Inhibitors for Combating the Menace of Tuberculosis. J Med Chem 61:8563-8593 (2018) [PubMed]  Article
Target
Name:
Decaprenylphosphoryl-beta-D-ribose oxidase
Synonyms:
DPRE1_MYCTU | Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase | Decaprenylphosphoryl-beta-D-ribose 2-epimerase flavoprotein subunit | Decaprenylphosphoryl-beta-D-ribose oxidase | FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase | dprE1
Type:
PROTEIN
Mol. Mass.:
50167.60
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
ChEMBL_116793
Residue:
461
Sequence:
MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSYGDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQVTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRHLTPTGEDAELFWATVGGNGLTGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKLGRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKSGTYRGKVQNLTQFYHPLDMFGEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHYSFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFVSELDRRVLEFGGRLYTAKDSRTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL
  
Inhibitor
Name:
BDBM50517942
Synonyms:
CHEMBL4475286
Type:
Small organic molecule
Emp. Form.:
C15H13N5O4S
Mol. Mass.:
359.36
SMILES:
CCOC(=O)NC(=O)c1ccsc1NC(=O)c1ccn2cnnc2c1
Structure:
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