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Target
Serine/threonine-protein kinase 17A
Ligand
BDBM50520152
Substrate
n/a
Meas. Tech.
ChEMBL_1879132 (CHEMBL4380526)
IC50
25±n/a nM
Citation
 Lefranc, J; Schulze, VK; Hillig, RC; Briem, H; Prinz, F; Mengel, A; Heinrich, T; Balint, J; Rengachari, S; Irlbacher, H; Stöckigt, D; Bömer, U; Bader, B; Gradl, SN; Nising, CF; von Nussbaum, F; Mumberg, D; Panne, D; Wengner, AM Discovery of BAY-985, a Highly Selective TBK1/IKK? Inhibitor. J Med Chem 63:601-612 (2020) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase 17A
Synonyms:
DRAK1 | ST17A_HUMAN | STK17A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46544.04
Organism:
Homo sapiens (Human)
Description:
gi_109255245
Residue:
414
Sequence:
MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
  
Inhibitor
Name:
BDBM50520152
Synonyms:
CHEMBL4594167 | US10894784, Example 150.02
Type:
Small organic molecule
Emp. Form.:
C25H26F3N9O
Mol. Mass.:
525.5288
SMILES:
CNc1cc(ncn1)-c1ccc2nc(Nc3cc(CN4CCN(CC4)C(=O)CC(F)(F)F)ccn3)[nH]c2c1
Structure:
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