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Target
Capsid scaffolding protein
Ligand
BDBM50075163
Substrate
n/a
Meas. Tech.
ChEBML_82457
IC50
260±n/a nM
Citation
 Jarvest, RL; Pinto, IL; Ashman, SM; Dabrowski, CE; Fernandez, AV; Jennings, LJ; Lavery, P; Tew, DG Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones. Bioorg Med Chem Lett 9:443-8 (1999) [PubMed]
Target
Name:
Capsid scaffolding protein
Synonyms:
Human herpesvirus 2 protease | SCAF_HHV2H | UL26
Type:
PROTEIN
Mol. Mass.:
66947.39
Organism:
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus2)
Description:
ChEMBL_82452
Residue:
637
Sequence:
MASAEMRERLEAPLPDRAVPIYVAGFLALYDSGDPGELALDPDTVRAALPPENPLPINVDHRARCEVGRVLAVVNDPRGPFFVGLIACVQLERVLETAASAAIFERRGPALSREERLLYLITNYLPSVSLSTKRRGDEVPPDRTLFAHVALCAIGRRLGTIVTYDTSLDAAIAPFRHLDPATREGVRREAAEAELALAGRTWAPGVEALTHTLLSTAVNNMMLRDRWSLVAERRRQAGIAGHTYLQASEKFKIWGAESAPAPERGYKTGAPGAMDTSPAASVPAPQVAVRARQVASSSSSSSFPAPADMNPVSASGAPAPPPPGDGSYLWIPASHYNQLVTGQSAPRHPPLTACGLPAAGTVAYGHPGAGPSPHYPPPPAHPYPGMLFAGPSPLEAQIAALVGAIAADRQAGGLPAAAGDHGIRGSAKRRRHEVEQPEYDCGRDEPDRDFPYYPGEARPEPRPVDSRRAARQASGPHETITALVGAVTSLQQELAHMRARTHAPYGPYPPVGPYHHPHADTETPAQPPRYPAKAVYLPPPHIAPPGPPLSGAVPPPSYPPVAVTPGPAPPLHQPSPAHAHPPPPPPGPTPPPAASLPQPEAPGAEAGALVNASSAAHVNVDTARAADLFVSQMMGSR
  
Inhibitor
Name:
BDBM50075163
Synonyms:
(E)-N-[(S)-1-(5-Methyl-4-oxo-4H-thieno[2,3-d][1,3]oxazin-2-yl)-ethyl]-3-phenyl-3-thiophen-2-yl-acrylamide | CHEMBL138320
Type:
Small organic molecule
Emp. Form.:
C22H18N2O3S2
Mol. Mass.:
422.52
SMILES:
C[C@H](NC(=O)\C=C(\c1cccs1)c1ccccc1)c1nc2scc(C)c2c(=O)o1
Structure:
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