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Target
Interstitial collagenase
Ligand
BDBM50076342
Substrate
n/a
Meas. Tech.
ChEMBL_106319 (CHEMBL714731)
Ki
1500±n/a nM
Citation
 Jacobsen, EJ; Mitchell, MA; Hendges, SK; Belonga, KL; Skaletzky, LL; Stelzer, LS; Lindberg, TJ; Fritzen, EL; Schostarez, HJ; O'Sullivan, TJ; Maggiora, LL; Stuchly, CW; Laborde, AL; Kubicek, MF; Poorman, RA; Beck, JM; Miller, HR; Petzold, GL; Scott, PS; Truesdell, SE; Wallace, TL; Wilks, JW; Fisher, C; Goodman, LV; Kaytes, PS Synthesis of a series of stromelysin-selective thiadiazole urea matrix metalloproteinase inhibitors. J Med Chem 42:1525-36 (1999) [PubMed]  Article
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50076342
Synonyms:
1-[(S)-1-Benzyl-2-oxo-2-(4-pyridin-2-yl-piperazin-1-yl)-ethyl]-3-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-urea | CHEMBL290857
Type:
Small organic molecule
Emp. Form.:
C21H23N7O2S2
Mol. Mass.:
469.583
SMILES:
Sc1nnc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCN(CC2)c2ccccn2)s1
Structure:
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