Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50078454
Substrate
n/a
Meas. Tech.
ChEMBL_162021 (CHEMBL772961)
IC50
15.3±n/a nM
Citation
Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH Structure-activity relationships for a class of inhibitors of purine nucleoside phosphorylase. J Med Chem 42:2422-31 (1999) [PubMed] Article
More Info.:
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | NP | PNP | PNPH_BOVIN | Purine Nucleoside Phosphorylase (PNP) | Purine nucleoside phosphorylase
Type:
Enzyme
Mol. Mass.:
32035.18
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
289
Sequence:
MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
Inhibitor
Name:
BDBM50078454
Synonyms:
2-Amino-7-pyridin-2-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one | 2-amino-7-(pyridin-2-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one | CHEMBL315260
Type:
Small organic molecule
Emp. Form.:
C12H11N5O
Mol. Mass.:
241.2486
SMILES:
Nc1nc2c(Cc3ccccn3)c[nH]c2c(=O)[nH]1