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Target
Folate receptor alpha
Ligand
BDBM50529284
Substrate
n/a
Meas. Tech.
ChEMBL_1908223 (CHEMBL4410581)
IC50
1.4±n/a nM
Citation
 Xiang, W; Dekhne, A; Doshi, A; O'Connor, C; Hou, Z; Matherly, LH; Gangjee, A Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor ? and inhibition of de novo purine nucleotide biosynthesis. Bioorg Med Chem 27:0 (2019) [PubMed]  Article
Target
Name:
Folate receptor alpha
Synonyms:
Adult folate-binding protein | FBP | FOLR | FOLR1 | FOLR1_HUMAN | FR-alpha | Folate receptor 1 | Folate receptor, adult | KB cells FBP | Ovarian tumor-associated antigen MOv18
Type:
PROTEIN
Mol. Mass.:
29827.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469596
Residue:
257
Sequence:
MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWAAWPFLLSLALMLLWLLS
  
Inhibitor
Name:
BDBM50529284
Synonyms:
CHEMBL4435608
Type:
Small organic molecule
Emp. Form.:
C21H22N6O7
Mol. Mass.:
470.4354
SMILES:
CN(Cc1cc2c(nc(N)[nH]c2=O)[nH]1)C(=O)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r|
Structure:
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