Reaction Details  Report a problem with these data
Target
Translocator protein
Ligand
BDBM50530439
Substrate
n/a
Meas. Tech.
ChEMBL_1912567 (CHEMBL4415150)
IC50
2.1±n/a nM
Citation
 Vanda, D; Zajdel, P; Soural, M Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases. Eur J Med Chem 181:0 (2019) [PubMed]  Article
Target
Name:
Translocator protein
Synonyms:
BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor-related protein | Peripheral-type benzodiazepine receptor | TSPO | TSPO_HUMAN
Type:
Enzyme
Mol. Mass.:
18834.74
Organism:
Homo sapiens (Human)
Description:
P30536
Residue:
169
Sequence:
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE
  
Inhibitor
Name:
BDBM50530439
Synonyms:
CHEMBL4456416
Type:
Small organic molecule
Emp. Form.:
C37H45ClN6O8
Mol. Mass.:
737.242
SMILES:
CCCN(CCC)C(=O)Cc1c(nc2c(CC(=O)CCCCC(=O)Nc3ccn([C@@H]4O[C@H](CO)[C@@H](O)[C@@H]4O)c(=O)n3)cccn12)-c1ccc(Cl)cc1 |r|
Structure:
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