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Target
Beta-lactamase
Ligand
BDBM50088835
Substrate
n/a
Meas. Tech.
ChEBML_47837
IC50
6±n/a nM
Citation
 Buynak, JD; Doppalapudi, VR; Adam, G The synthesis and evaluation of 3-substituted-7-(alkylidene)cephalosporin sulfones as beta-lactamase inhibitors. Bioorg Med Chem Lett 10:853-7 (2000) [PubMed]
Target
Name:
Beta-lactamase
Synonyms:
Beta-lactamase TEM
Type:
PROTEIN
Mol. Mass.:
31512.33
Organism:
Enterobacter cloacae
Description:
ChEMBL_41358
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM50088835
Synonyms:
CHEMBL433726 | Sodium; (R)-5,5,8-trioxo-3-[(E)-2-(1-oxy-pyridin-2-yl)-vinyl]-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C20H14N3O6S
Mol. Mass.:
424.407
SMILES:
[O-]C(=O)C1=C(CS(=O)(=O)[C@H]2N1C(=O)\C2=C\c1ccccn1)\C=C\c1cccc[n+]1[O-] |t:3|
Structure:
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