Reaction Details  Report a problem with these data
Target
Solute carrier family 22 member 6
Ligand
BDBM50537500
Substrate
n/a
Meas. Tech.
ChEMBL_1936428 (CHEMBL4482187)
IC50
4400±n/a nM
Citation
 Li, X; Qiao, Y; Wang, X; Ma, R; Li, T; Zhang, Y; Borris, RP Dihydrophenanthrenes from Juncus effusus as Inhibitors of OAT1 and OAT3. J Nat Prod 82:832-839 (2019) [PubMed]  Article
Target
Name:
Solute carrier family 22 member 6
Synonyms:
OAT1 | Organic anion transporter 1 | PAH transporter | PAHT | Renal organic anion transporter 1 | S22A6_HUMAN | SLC22A6 | hOAT1 | hPAHT | hROAT1
Type:
PROTEIN
Mol. Mass.:
61831.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1487359
Residue:
563
Sequence:
MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQTRQQQEHQKYMVPLQASAQEKNGL
  
Inhibitor
Name:
BDBM50537500
Synonyms:
CHEMBL4562825
Type:
Small organic molecule
Emp. Form.:
C18H16O3
Mol. Mass.:
280.3178
SMILES:
Cc1c(O)ccc-2c1CCc1cc(cc(C=C)c-21)C(O)=O
Structure:
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