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Target
Prostacyclin receptor
Ligand
BDBM50095202
Substrate
n/a
Meas. Tech.
ChEBML_158015
Ki
80±n/a nM
Citation
 Tsubaki, K; Taniguchi, K; Tabuchi, S; Okitsu, O; Hattori, K; Seki, J; Sakane, K; Tanaka, H A novel pyridazinone derivative as a nonprostanoid PGI2 agonist. Bioorg Med Chem Lett 10:2787-90 (2000) [PubMed]
Target
Name:
Prostacyclin receptor
Synonyms:
PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40968.22
Organism:
Homo sapiens (Human)
Description:
The membranes prepared from human platelet were used in binding assay.
Residue:
386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
  
Inhibitor
Name:
BDBM50095202
Synonyms:
4-[2-Hydroxy-3-((E)-3-hydroxy-4-methyl-oct-1-en-6-ynyl)-3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]furan-7-yl]-butyric acid | CHEMBL94694
Type:
Small organic molecule
Emp. Form.:
C24H29O5
Mol. Mass.:
397.4846
SMILES:
CC#CCC(C)[C@H](O)\C=C\[C@H]1[C@H](O)CC2Oc3c(cccc3CCCC([O-])=O)[C@H]12
Structure:
Search PDB for entries with ligand similarity: