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Target
Carnitine O-palmitoyltransferase 1, liver isoform
Ligand
BDBM50101605
Substrate
n/a
Meas. Tech.
ChEMBL_46317 (CHEMBL663461)
IC50
>300000±n/a nM
Citation
 Giannessi, F; Chiodi, P; Marzi, M; Minetti, P; Pessotto, P; De Angelis, F; Tassoni, E; Conti, R; Giorgi, F; Mabilia, M; Dell'Uomo, N; Muck, S; Tinti, MO; Carminati, P; Arduini, A Reversible carnitine palmitoyltransferase inhibitors with broad chemical diversity as potential antidiabetic agents. J Med Chem 44:2383-6 (2001) [PubMed]
Target
Name:
Carnitine O-palmitoyltransferase 1, liver isoform
Synonyms:
CPT I | CPT1-L | CPT1A_RAT | CPTI-L | Carnitine O-palmitoyltransferase I, liver isoform | Carnitine palmitoyltransferase 1A | Cpt-1 | Cpt1 | Cpt1a
Type:
PROTEIN
Mol. Mass.:
88147.11
Organism:
Rattus norvegicus
Description:
ChEMBL_887445
Residue:
773
Sequence:
MAEAHQAVAFQFTVTPDGIDLRLSHEALKQICLSGLHSWKKKFIRFKNGIITGVFPANPSSWLIVVVGVISSMHAKVDPSLGMIAKISRTLDTTGRMSSQTKNIVSGVLFGTGLWVAVIMTMRYSLKVLLSYHGWMFAEHGKMSRSTKIWMAMVKVLSGRKPMLYSFQTSLPRLPVPAVKDTVSRYLESVRPLMKEEDFQRMTALAQDFAVNLGPKLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMEMLYITPTHIQAARAGNTIHAILLYRRTLDREELKPIRLLGSTIPLCSAQWERLFNTSRIPGEETDTIQHIKDSRHIVVYHRGRYFKVWLYHDGRLLRPRELEQQMQQILDDPSEPQPGEAKLAALTAADRVPWAKCRQTYFARGKNKQSLDAVEKAAFFVTLDESEQGYREEDPEASIDSYAKSLLHGRCFDRWFDKSITFVVFKNSKIGINAEHSWADAPVVGHLWEYVMATDVFQLGYSEDGHCKGDTNPNIPKPTRLQWDIPGECQEVIDASLSSASLLANDVDLHSFPFDSFGKGLIKKCRTSPDAFIQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTMESCNFVQAMMDPKSTAEQRLKLFKIACEKHQHLYRLAMTGAGIDRHLFCLYVVSKYLAVDSPFLKEVLSEPWRLSTSQTPQQQVELFDFEKNPDYVSCGGGFGPVADDGYGVSYIIVGENFIHFHISSKFSSPETDSHRFGKHLRQAMMDIITLFGLTINSKK
  
Inhibitor
Name:
BDBM50101605
Synonyms:
1-(3-Phosphono-2-tetradecyloxycarbonyloxy-propyl)-1-azonia-bicyclo[2.2.2]octane | CHEMBL77014
Type:
Small organic molecule
Emp. Form.:
C25H48NO6P
Mol. Mass.:
489.6255
SMILES:
CCCCCCCCCCCCCCOC(=O)OC(C[N+]12CCC(CC1)CC2)CP(O)([O-])=O
Structure:
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