Reaction Details  Report a problem with these data
Target
Alpha-synuclein
Ligand
BDBM50545093
Substrate
n/a
Meas. Tech.
ChEMBL_1994333 (CHEMBL4628228)
Kd
344±n/a nM
Citation
 Chen, YF; Bian, J; Zhang, P; Bu, LL; Shen, Y; Yu, WB; Lu, XH; Lin, X; Ye, DY; Wang, J; Chu, Y Design, synthesis and identification of N, N-dibenzylcinnamamide (DBC) derivatives as novel ligands for ?-synuclein fibrils by SPR evaluation system. Bioorg Med Chem 28:0 (2020) [PubMed]  Article
Target
Name:
Alpha-synuclein
Synonyms:
NACP | PARK1 | SNCA | SYUA_HUMAN
Type:
Protein
Mol. Mass.:
14451.42
Organism:
Homo sapiens (Human)
Description:
P37840
Residue:
140
Sequence:
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA
  
Inhibitor
Name:
BDBM50545093
Synonyms:
CHEMBL4645133
Type:
Small organic molecule
Emp. Form.:
C28H29N3O4
Mol. Mass.:
471.5476
SMILES:
CC(C)(C)NC(=O)c1ccc(\C=C\C(=O)N(Cc2ccccc2)Cc2ccccc2[N+]([O-])=O)cc1
Structure:
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