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Target
STE20/SPS1-related proline-alanine-rich protein kinase
Ligand
BDBM50560434
Substrate
n/a
Meas. Tech.
ChEMBL_2072182 (CHEMBL4727716)
IC50
>50000±n/a nM
Citation
 Fujii, S; Kikuchi, E; Watanabe, Y; Suzuyama, H; Ishigami-Yuasa, M; Mori, T; Isobe, K; Uchida, S; Kagechika, H Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article
Target
Name:
STE20/SPS1-related proline-alanine-rich protein kinase
Synonyms:
DCHT | SPAK | STK39 | STK39_HUMAN | Serine/threonine-protein kinase 39 | Ste-20-related kinase
Type:
PROTEIN
Mol. Mass.:
59471.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774551
Residue:
545
Sequence:
MAEPSGSPVHVQLPQQAAPVTAAAAAAPAAATAAPAPAAPAAPAPAPAPAAQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSASTIPEQIQSLSVHDSQGPPNANEDYREASSCAVNLVLRLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFAQLSVS
  
Inhibitor
Name:
BDBM50560434
Synonyms:
CHEMBL4744081
Type:
Small organic molecule
Emp. Form.:
C23H15BrClNO2
Mol. Mass.:
452.728
SMILES:
Clc1cc(NC(=O)c2ccccc2)ccc1Oc1ccc2ccccc2c1Br
Structure:
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