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Target
Tyrosine-protein kinase receptor Tie-1
Ligand
BDBM50097956
Substrate
n/a
Meas. Tech.
ChEMBL_2125055 (CHEMBL4834288)
IC50
2500±n/a nM
Citation
 Mathison, CJN; Yang, Y; Nelson, J; Huang, Z; Jiang, J; Chianelli, D; Rucker, PV; Roland, J; Xie, YF; Epple, R; Bursulaya, B; Lee, C; Gao, MY; Shaffer, J; Briones, S; Sarkisova, Y; Galkin, A; Li, L; Li, N; Li, C; Hua, S; Kasibhatla, S; Kinyamu-Akunda, J; Kikkawa, R; Molteni, V; Tellew, JE Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3- ACS Med Chem Lett 12:1912-1919 (2021) [PubMed]  Article
Target
Name:
Tyrosine-protein kinase receptor Tie-1
Synonyms:
TIE | TIE1 | TIE1_HUMAN
Type:
PROTEIN
Mol. Mass.:
125096.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498731
Residue:
1138
Sequence:
MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPPLLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
  
Inhibitor
Name:
BDBM50097956
Synonyms:
3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-phenol | 3-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenol | CHEMBL169390
Type:
Small organic molecule
Emp. Form.:
C17H18N4O
Mol. Mass.:
294.351
SMILES:
Nc1ncnc2n(cc(-c3cccc(O)c3)c12)C1CCCC1
Structure:
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