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Target
Probable periplasmic serine endoprotease DegP-like
Ligand
BDBM50577901
Substrate
n/a
Meas. Tech.
ChEMBL_2131302 (CHEMBL4840817)
IC50
4570±n/a nM
Citation
 Hwang, J; Strange, N; Phillips, MJA; Krause, AL; Heywood, A; Gamble, AB; Huston, WM; Tyndall, JDA Optimization of peptide-based inhibitors targeting the HtrA serine protease in Chlamydia: Design, synthesis and biological evaluation of pyridone-based and N-Capping group-modified analogues. Eur J Med Chem 224:0 (2021) [PubMed]  Article
Target
Name:
Probable periplasmic serine endoprotease DegP-like
Synonyms:
3.4.21.107 | 59 kDa immunogenic protein | DEGPL_CHLTR | Probable periplasmic serine endoprotease DegP-like | Protease Do | SK59 | htrA
Type:
PROTEIN
Mol. Mass.:
53244.42
Organism:
Chlamydia trachomatis (strain D/UW-3/Cx)
Description:
ChEMBL_120509
Residue:
497
Sequence:
MMKRLLCVLLSTSVFSSPMLGYSASKKDSKADICLAVSSGDQEVSQEDLLKEVSRGFSRVAAKATPGVVYIENFPKTGNQAIASPGNKRGFQENPFDYFNDEFFNRFFGLPSHREQQRPQQRDAVRGTGFIVSEDGYVVTNHHVVEDAGKIHVTLHDGQKYTAKIVGLDPKTDLAVIKIQAEKLPFLTFGNSDQLQIGDWAIAIGNPFGLQATVTVGVISAKGRNQLHIVDFEDFIQTDAAINPGNSGGPLLNINGQVIGVNTAIVSGSGGYIGIGFAIPSLMAKRVIDQLISDGQVTRGFLGVTLQPIDSELATCYKLEKVYGALVTDVVKGSPAEKAGLRQEDVIVAYNGKEVESLSALRNAISLMMPGTRVVLKIVREGKTIEIPVTVTQIPTEDGVSALQKMGVRVQNITPEICKKLGLAADTRGILVVAVEAGSPAASAGVAPGQLILAVNRQRVASVEELNQVLKNSKGENVLLMVSQGDVVRFIVLKSDE
  
Inhibitor
Name:
BDBM50577901
Synonyms:
CHEMBL4872003
Type:
Small organic molecule
Emp. Form.:
C33H48N3O6P
Mol. Mass.:
613.7245
SMILES:
CCC(C)C(NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)C(C)(C)C)C(C)(C)C)P(=O)(Oc1ccccc1)Oc1ccccc1 |r|
Structure:
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