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Target
Ubiquitin carboxyl-terminal hydrolase 2
Ligand
BDBM50591324
Substrate
n/a
Meas. Tech.
ChEMBL_2200012 (CHEMBL5112528)
IC50
3800±n/a nM
Citation
 Tan, L; Shan, H; Han, C; Zhang, Z; Shen, J; Zhang, X; Xiang, H; Lu, K; Qi, C; Li, Y; Zhuang, G; Chen, G; Tan, L Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer. J Med Chem 65:13645-13659 (2022) [PubMed]  Article
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 2
Synonyms:
41 kDa ubiquitin-specific protease | Deubiquitinating enzyme 2 | UBP2_HUMAN | UBP41 | USP2 | Ubiquitin thioesterase 2 | Ubiquitin-specific-processing protease 2
Type:
PROTEIN
Mol. Mass.:
68093.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103660
Residue:
605
Sequence:
MSQLSSTLKRYTESARYTDAHYAKSGYGAYTPSSYGANLAASLLEKEKLGFKPVPTSSFLTRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERPLGSGLSGGSGFPYGVTNNCLSYLPINAYDQGVTLTQKLDSQSDLARDFSSLRTSDSYRIDPRNLGRSPMLARTRKELCTLQGLYQTASCPEYLVDYLENYGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETGKGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM
  
Inhibitor
Name:
BDBM50591324
Synonyms:
CHEMBL5185273
Type:
Small organic molecule
Emp. Form.:
C22H16ClFN2O4
Mol. Mass.:
426.825
SMILES:
CN1CC[C@H](C1)Oc1ccc(F)c(-c2nc3c(o2)C(=O)c2ccccc2C3=O)c1Cl |r|
Structure:
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