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Target
Methionine aminopeptidase
Ligand
BDBM50175431
Substrate
n/a
Meas. Tech.
ChEMBL_326946 (CHEMBL853287)
IC50
1710±n/a nM
Citation
 Huang, QQ; Huang, M; Nan, FJ; Ye, QZ Metalloform-selective inhibition: synthesis and structure-activity analysis of Mn(II)-form-selective inhibitors of Escherichia coli methionine aminopeptidase. Bioorg Med Chem Lett 15:5386-91 (2005) [PubMed]  Article
Target
Name:
Methionine aminopeptidase
Synonyms:
EcMetAP | MAP1_ECOLI | Methionine Aminopeptidase (MAP) | Methionine aminopeptidase | Peptidase M | map
Type:
Enzyme
Mol. Mass.:
29326.96
Organism:
Escherichia coli (strain K12)
Description:
Full-length untagged EcMAP was expressed in E. coli.
Residue:
264
Sequence:
MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
  
Inhibitor
Name:
BDBM50175431
Synonyms:
5-(2-chloro-3-methylphenyl)furan-2-carboxylic acid | CHEMBL200376
Type:
Small organic molecule
Emp. Form.:
C12H9ClO3
Mol. Mass.:
236.651
SMILES:
Cc1cccc(-c2ccc(o2)C(O)=O)c1Cl
Structure:
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