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Target
Alpha-ketoglutarate-dependent dioxygenase FTO
Ligand
BDBM50599018
Substrate
n/a
Meas. Tech.
ChEMBL_2228866 (CHEMBL5142379)
IC50
670±n/a nM
Citation
 Huff, S; Kummetha, IR; Zhang, L; Wang, L; Bray, W; Yin, J; Kelley, V; Wang, Y; Rana, TM Rational Design and Optimization of m J Med Chem 65:10920-10937 (2022) [PubMed]  Article
Target
Name:
Alpha-ketoglutarate-dependent dioxygenase FTO
Synonyms:
FTO | FTO_HUMAN | Fat mass and obesity-associated protein | KIAA1752
Type:
PROTEIN
Mol. Mass.:
58263.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1515854
Residue:
505
Sequence:
MKRTPTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRIQGKDLLTPVSRILIGNPGCTYKYLNTRLFTVPWPVKGSNIKHTEAEIAAACETFLKLNDYLQIETIQALEELAAKEKANEDAVPLCMSADFPRVGMGSSYNGQDEVDIKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGPEEESEDDSHLEGRDPDIWHVGFKISWDIETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVCDDVDNDDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYRKCTDWWCQPMAQLEALWKKMEGVTNAVLHEVKREGLPVEQRNEILTAILASLTARQNLRREWHARCQSRIARTLPADQKPECRPYWEKDDASMPLPFDLTDIVSELRGQLLEAKP
  
Inhibitor
Name:
BDBM50599018
Synonyms:
CHEMBL5186890 | US20230322715, Compound TR-FTO-27
Type:
Small organic molecule
Emp. Form.:
C17H24N2O3
Mol. Mass.:
304.3841
SMILES:
C(NCC1(COC1)N1CCCC1)c1ccc2OCCOc2c1
Structure:
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