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Target
M-phase inducer phosphatase 2
Ligand
BDBM50181025
Substrate
n/a
Meas. Tech.
ChEMBL_345890 (CHEMBL860851)
IC50
4850±n/a nM
Citation
 Huang, W; Li, J; Zhang, W; Zhou, Y; Xie, C; Luo, Y; Li, Y; Wang, J; Li, J; Lu, W Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett 16:1905-8 (2006) [PubMed]  Article
Target
Name:
M-phase inducer phosphatase 2
Synonyms:
CDC25B | CDC25HU2 | Dual specificity phosphatase (CDC25B) | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2 (CDC25B) | MPIP2_HUMAN
Type:
Protein
Mol. Mass.:
64985.27
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
580
Sequence:
MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ
  
Inhibitor
Name:
BDBM50181025
Synonyms:
CHEMBL208488 | N-(4-(2-isopropyl-8,8-dimethyl-3,4-dioxo-3,4,5,6,7,8-hexahydrophenanthren-1-ylthio)phenyl)acetamide
Type:
Small organic molecule
Emp. Form.:
C27H29NO3S
Mol. Mass.:
447.589
SMILES:
CC(C)C1=C(Sc2ccc(NC(C)=O)cc2)c2ccc3c(CCCC3(C)C)c2C(=O)C1=O |c:3|
Structure:
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