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Target
Probable periplasmic serine endoprotease DegP-like
Ligand
BDBM50603190
Substrate
n/a
Meas. Tech.
ChEMBL_2243355 (CHEMBL5157565)
IC50
15260±n/a nM
Citation
 Hwang, J; Strange, N; Mazraani, R; Phillips, MJ; Gamble, AB; Huston, WM; Tyndall, JDA Design, synthesis and biological evaluation of P2-modified proline analogues targeting the HtrA serine protease in Chlamydia. Eur J Med Chem 230:0 (2022) [PubMed]  Article
Target
Name:
Probable periplasmic serine endoprotease DegP-like
Synonyms:
3.4.21.107 | 59 kDa immunogenic protein | DEGPL_CHLTR | Probable periplasmic serine endoprotease DegP-like | Protease Do | SK59 | htrA
Type:
PROTEIN
Mol. Mass.:
53244.42
Organism:
Chlamydia trachomatis (strain D/UW-3/Cx)
Description:
ChEMBL_120509
Residue:
497
Sequence:
MMKRLLCVLLSTSVFSSPMLGYSASKKDSKADICLAVSSGDQEVSQEDLLKEVSRGFSRVAAKATPGVVYIENFPKTGNQAIASPGNKRGFQENPFDYFNDEFFNRFFGLPSHREQQRPQQRDAVRGTGFIVSEDGYVVTNHHVVEDAGKIHVTLHDGQKYTAKIVGLDPKTDLAVIKIQAEKLPFLTFGNSDQLQIGDWAIAIGNPFGLQATVTVGVISAKGRNQLHIVDFEDFIQTDAAINPGNSGGPLLNINGQVIGVNTAIVSGSGGYIGIGFAIPSLMAKRVIDQLISDGQVTRGFLGVTLQPIDSELATCYKLEKVYGALVTDVVKGSPAEKAGLRQEDVIVAYNGKEVESLSALRNAISLMMPGTRVVLKIVREGKTIEIPVTVTQIPTEDGVSALQKMGVRVQNITPEICKKLGLAADTRGILVVAVEAGSPAASAGVAPGQLILAVNRQRVASVEELNQVLKNSKGENVLLMVSQGDVVRFIVLKSDE
  
Inhibitor
Name:
BDBM50603190
Synonyms:
CHEMBL5202270
Type:
Small organic molecule
Emp. Form.:
C35H51N4O9P
Mol. Mass.:
702.7746
SMILES:
CC(C)C(NC(=O)[C@@H]1C[C@H](CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)OC(=O)CCN)P(=O)(Oc1ccccc1)Oc1ccccc1 |r|
Structure:
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