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Target
Relaxin-3 receptor 1
Ligand
BDBM50605996
Substrate
n/a
Meas. Tech.
ChEMBL_2253271 (CHEMBL5167481)
IC50
7900±n/a nM
Citation
 Gay, EA; Guan, D; Van Voorhies, K; Vasukuttan, V; Mathews, KM; Besheer, J; Jin, C Discovery and Characterization of the First Nonpeptide Antagonists for the Relaxin-3/RXFP3 System. J Med Chem 65:7959-7974 (2022) [PubMed]  Article
Target
Name:
Relaxin-3 receptor 1
Synonyms:
G protein-coupled receptor SALPR | G-protein coupled receptor GPCR135 | GPCR135 | RL3R1_HUMAN | RLN3 receptor 1 | RLN3R1 | RXFP3 | Relaxin family peptide receptor 3 | SALPR | Somatostatin- and angiotensin-like peptide receptor
Type:
PROTEIN
Mol. Mass.:
51139.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_818423
Residue:
469
Sequence:
MQMADAATIATMNKAAGGDKLAELFSLVPDLLEAANTSGNASLQLPDLWWELGLELPDGAPPGHPPGSGGAESADTEARVRILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGDCCGRSLGDSCCFSAKALCVWIWALAALASLPSAIFSTTVKVMGEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKALKSLLWRIASPSITSMRPFTATTKPEHEDQGLQAPAPPHAAAEPDLLYYPPGVVVYSGGRYDLLPSSSAY
  
Inhibitor
Name:
BDBM50605996
Synonyms:
CHEMBL5191162
Type:
Small organic molecule
Emp. Form.:
C28H26N4O4
Mol. Mass.:
482.5304
SMILES:
COc1ccc(CN2CC(CC2=O)C(=O)Nc2ccc(cc2)-c2nc(no2)-c2ccc(C)cc2)cc1
Structure:
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