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Target
Serine/threonine-protein kinase 17A
Ligand
BDBM50606014
Substrate
n/a
Meas. Tech.
ChEMBL_2253368 (CHEMBL5167578)
IC50
31±n/a nM
Citation
 Kurz, CG; Preuss, F; Tjaden, A; Cusack, M; Amrhein, JA; Chatterjee, D; Mathea, S; Berger, LM; Berger, BT; Krämer, A; Weller, M; Weiss, T; Müller, S; Knapp, S; Hanke, T Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5- J Med Chem 65:7799-7817 (2022) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase 17A
Synonyms:
DRAK1 | ST17A_HUMAN | STK17A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46544.04
Organism:
Homo sapiens (Human)
Description:
gi_109255245
Residue:
414
Sequence:
MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
  
Inhibitor
Name:
BDBM50606014
Synonyms:
CHEMBL5193635
Type:
Small organic molecule
Emp. Form.:
C25H25N5O3
Mol. Mass.:
443.4977
SMILES:
CC(NC(=O)c1ccc-2cc1OCCOCCNc1ccn3ncc-2c3n1)c1ccccc1
Structure:
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