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Target
Receptor-type tyrosine-protein phosphatase alpha
Ligand
BDBM50607111
Substrate
n/a
Meas. Tech.
ChEMBL_2262146 (CHEMBL5217157)
IC50
>10000±n/a nM
Citation
 He, R; Wang, J; Yu, ZH; Moyers, JS; Michael, MD; Durham, TB; Cramer, JW; Qian, Y; Lin, A; Wu, L; Noinaj, N; Barrett, DG; Zhang, ZY Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors. J Med Chem 65:13892-13909 (2022) [PubMed]  Article
Target
Name:
Receptor-type tyrosine-protein phosphatase alpha
Synonyms:
PTPA | PTPRA | PTPRA_HUMAN | PTPRL2 | Protein-tyrosine phosphatase alpha
Type:
Enzyme
Mol. Mass.:
90719.02
Organism:
Homo sapiens (Human)
Description:
P18433
Residue:
802
Sequence:
MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLSVAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK
  
Inhibitor
Name:
BDBM50607111
Synonyms:
CHEMBL5218807
Type:
Small organic molecule
Emp. Form.:
C8H8Br2N2O4S
Mol. Mass.:
388.033
SMILES:
Cc1c(Br)cc(NC(=O)NS(O)(=O)=O)cc1Br
Structure:
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