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Target
Sphingolipid delta(4)-desaturase DES1
Ligand
BDBM523243
Substrate
n/a
Meas. Tech.
ChEMBL_2266697
IC50
4.0±n/a nM
Citation
 Skácel, J; Slusher, BS; Tsukamoto, T Small Molecule Inhibitors Targeting Biosynthesis of Ceramide, the Central Hub of the Sphingolipid Network. J Med Chem 64:279-297 (2021) [PubMed]
Target
Name:
Sphingolipid delta(4)-desaturase DES1
Synonyms:
Cell migration-inducing gene 15 protein | DEGS1 | DEGS1_HUMAN | DES1 | Degenerative spermatocyte homolog 1 | MLD | Membrane lipid desaturase
Type:
PROTEIN
Mol. Mass.:
37872.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_816893
Residue:
323
Sequence:
MGSRVSREDFEWVYTDQPHADRRREILAKYPEIKSLMKPDPNLIWIIIMMVLTQLGAFYIVKDLDWKWVIFGAYAFGSCINHSMTLAIHEIAHNAAFGNCKAMWNRWFGMFANLPIGIPYSISFKRYHMDHHRYLGADGVDVDIPTDFEGWFFCTAFRKFIWVILQPLFYAFRPLFINPKPITYLEVINTVAQVTFDILIYYFLGIKSLVYMLAASLLGLGLHPISGHFIAEHYMFLKGHETYSYYGPLNLLTFNVGYHNEHHDFPNIPGKSLPLVRKIAAEYYDNLPHYNSWIKVLYDFVMDDTISPYSRMKRHQKGEMVLE
  
Inhibitor
Name:
BDBM523243
Synonyms:
N-(5-hydroxy- pyridin-2-yl)- 4-cyclohexyl- benzamide | US11135207, Example 20
Type:
Small organic molecule
Emp. Form.:
C18H20N2O2
Mol. Mass.:
296.3636
SMILES:
Oc1ccc(NC(=O)c2ccc(cc2)C2CCCCC2)nc1
Structure:
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