Reaction Details  Report a problem with these data
Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50193680
Substrate
n/a
Meas. Tech.
ChEMBL_421374 (CHEMBL856556)
EC50
190±n/a nM
Citation
 Jiang, J; Hoang, M; Young, JR; Chaung, D; Eid, R; Turner, C; Lin, P; Tong, X; Wang, J; Tan, C; Feighner, S; Palyha, O; Hreniuk, DL; Pan, J; Sailer, AW; MacNeil, DJ; Howard, A; Shearman, L; Stribling, S; Camacho, R; Strack, A; Van der Ploeg, LH; Goulet, MT; DeVita, RJ 2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists. Bioorg Med Chem Lett 16:5270-4 (2006) [PubMed]  Article
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | Gpr24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCH1R | MCHR | MCHR-1 | MCHR1_RAT | Mchr1 | Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 | SLC-1 | Slc1 | Somatostatin receptor-like protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39075.64
Organism:
RAT
Description:
Melanin Concentrating Hormone 1 GPR24 RAT::P97639
Residue:
353
Sequence:
MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50193680
Synonyms:
CHEMBL217207 | N-(2-(2-azabicyclo[2.2.2]octan-2-yl)quinolin-6-yl)-3-(4-(trifluoromethyl)phenyl)propanamide
Type:
Small organic molecule
Emp. Form.:
C26H26F3N3O
Mol. Mass.:
453.4993
SMILES:
FC(F)(F)c1ccc(CCC(=O)Nc2ccc3nc(ccc3c2)N2CC3CCC2CC3)cc1 |THB:18:23:27.26:29.30,(1.65,-7.49,;1.65,-9.03,;.32,-9.8,;.31,-8.26,;2.99,-9.8,;4.32,-9.03,;5.65,-9.8,;5.65,-11.34,;6.98,-12.11,;8.31,-11.34,;9.64,-12.11,;9.64,-13.65,;10.98,-11.34,;12.31,-12.11,;12.31,-13.65,;13.64,-14.42,;14.98,-13.64,;16.32,-14.41,;17.65,-13.63,;17.64,-12.09,;16.3,-11.32,;14.98,-12.1,;13.64,-11.33,;18.99,-14.4,;19.16,-15.78,;20.7,-15.14,;22.07,-15.79,;21.81,-14.39,;20.46,-13.77,;20.55,-12.13,;20.98,-13.24,;4.32,-12.11,;2.99,-11.35,)|
Structure:
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