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Target
Monocarboxylate transporter 1
Ligand
BDBM50608638
Substrate
n/a
Meas. Tech.
ChEMBL_2274359
IC50
13±n/a nM
Citation
 Puri, S; Juvale, K Monocarboxylate transporter 1 and 4 inhibitors as potential therapeutics for treating solid tumours: A review with structure-activity relationship insights. Eur J Med Chem 199:0 (2020) [PubMed]
Target
Name:
Monocarboxylate transporter 1
Synonyms:
MCT 1 | MOT1_RAT | Mct1 | Monocarboxylate transporter 1 | Monocarboxylate transporter 1 (MCT1) | Slc16a1 | Solute carrier family 16 member 1
Type:
Enzyme
Mol. Mass.:
53245.17
Organism:
Rattus norvegicus (Rat)
Description:
P53987
Residue:
494
Sequence:
MPPAIGGPVGYTPPDGGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLILGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQTVNKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVILIIAGLYLFIGMGINYRLVAKEQKAEEKKRDGKEDETSTDVDEKPKKTMKETQSPAPLQNSSGDPAEEESPV
  
Inhibitor
Name:
BDBM50608638
Synonyms:
CHEMBL4303684
Type:
Small organic molecule
Emp. Form.:
C18H12N2O2
Mol. Mass.:
288.3001
SMILES:
OC(=O)C(=C\c1cn(-c2ccccc2)c2ccccc12)\C#N
Structure:
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