Reaction Details  Report a problem with these data
Target
Coagulation factor XIII A chain [Q652E]
Ligand
BDBM50608714
Substrate
n/a
Meas. Tech.
ChEMBL_2274768
IC50
26±n/a nM
Citation
 Al-Horani, RA; Kar, S Factor XIIIa inhibitors as potential novel drugs for venous thromboembolism. Eur J Med Chem 200:0 (2020) [PubMed]
Target
Name:
Coagulation factor XIII A chain [Q652E]
Synonyms:
Coagulation factor XIII A (FXIIIa) | F13A | F13A1 | F13A_HUMAN
Type:
Protein
Mol. Mass.:
83261.26
Organism:
Homo sapiens (Human)
Description:
P00488[Q652E]
Residue:
732
Sequence:
MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDTNKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPVPIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETDTYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCLYVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDILLEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGNVNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKHGHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITDTYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITFRNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLLEQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVEFTNPLKETLRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYGELDVQIQRRPSM
  
Inhibitor
Name:
BDBM50608714
Synonyms:
CHEMBL5281897
Type:
Small organic molecule
Emp. Form.:
C19H25NO2
Mol. Mass.:
299.4073
SMILES:
O=C(CCCCCCCc1cc1=O)NCCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: