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Target
Cyclin-dependent kinase 3
Ligand
BDBM50609501
Substrate
n/a
Meas. Tech.
ChEMBL_2278039
IC50
1837±n/a nM
Citation
 Yang, B; Zhang, H; Li, N; Gao, L; Jiang, H; Kan, W; Yuan, H; Li, J; Zhao, D; Xiong, B; Zhou, Y; Guo, D; Liu, T Discovery of Novel  J Med Chem 65:15770-15788 (2022) [PubMed]
Target
Name:
Cyclin-dependent kinase 3
Synonyms:
CDK3 | CDK3/Cyclin E | CDK3_HUMAN | CDKN3 | Cyclin-dependent kinase 3 | Cyclin-dependent kinase 3 (CDK3)
Type:
Enzyme
Mol. Mass.:
35053.88
Organism:
Homo sapiens (Human)
Description:
Q00526
Residue:
305
Sequence:
MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH
  
Inhibitor
Name:
BDBM50609501
Synonyms:
CHEMBL5288241
Type:
Small organic molecule
Emp. Form.:
C30H26N6O3
Mol. Mass.:
518.5658
SMILES:
O[C@H](CNc1cncc(c1)-c1ccc2[nH]nc(NC(=O)c3ccc(NC(=O)C=C)cc3)c2c1)c1ccccc1 |r|
Structure:
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