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Target
Lysosomal alpha-glucosidase
Ligand
BDBM50613004
Substrate
n/a
Meas. Tech.
ChEMBL_2290742
Ki
0.770000±n/a nM
Citation
 Lu, L; Chen, J; Tao, W; Wang, Z; Liu, D; Zhou, J; Wu, X; Sun, H; Li, W; Tanabe, G; Muraoka, O; Zhao, B; Wu, L; Xie, W Design and Synthesis of Sulfonium Derivatives: A Novel Class of ?-Glucosidase Inhibitors with Potent In Vivo Antihyperglycemic Activities. J Med Chem 66:3484-3498 (2023) [PubMed]
Target
Name:
Lysosomal alpha-glucosidase
Synonyms:
Acidic alpha-glucosidase | Gaa | LYAG_RAT
Type:
PROTEIN
Mol. Mass.:
106191.24
Organism:
Rattus norvegicus
Description:
ChEMBL_1506157
Residue:
953
Sequence:
MNIRKPLCSNSVVGACTLVSLTTAVILGHLMLRELMLLPQDLHESSSGLWKTYRPHHQESYEPAPLHIQEHAEQLRAVPTQCDVTPNSRFDCAPDKGITQEQCEARGCCWVPAGQVLNGPVMGQPWCFFPPSYPSYRLENLSSTESGYTATLTRTSPTFFPKDVLTLQLEVLMETDSRLHFMIKDPTSKRYEVPLETPRVLSQAPSPLYSVEFSEEPFGVIVRRKLGGRVLLNTTVAPLFFADQFLQLSTSLPSQHIAGLGEHLSPLMLSTEWTRITLWNRDVAPSQGVNLYGSHPFYLALEDGGLAHGVFLLNSNAMDVVLQPSPALTWRSTGGILDVYVFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAIVRQVVENMTRTHFPLDVQWNDLDYMDARRDFTFNQDGFADFPDMVHELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKVWPGSTAFPDFTNPETLDWWQDMVSEFHAQVPFDGMWIDMNEPSNFIRGSQQGCPDNELENPPYVPGVVGGALQAATICASSHQFLSTHYNLHNLYGLTEAIASSRALVKTRGTRPFVISRSTFAGHGRYAGHWTGDVWSSWEHLAYSVPEILQFNLLGVPLVGADICGFQGNTTEELCVRWTQLGAFYPFMRNHNDLNSLPQEPYRFSETAQQAMRKAFTLRYALLPYLYTLFHGAHVKGDTVARPLFLEFPEDPSTWSVDRQLLWGPALLITPVLEPGKTDVTGYFPKGMWYNLQMVPVETLGSLPSSSPASSFRSIVHSKGQWLTLEAPLDTINVHLRAGYIIPLQGPSLTTTESRKQPMALAVALTESGEASGELFWDDGESLGVLERGAYTLVTFSAKNNTIVNKLVHVTKEGGELQLREVTILGVTTAPTQVLSNGISVSNFTYSPDDKSLSIPVSLLMGERFQIDWS
  
Inhibitor
Name:
BDBM50613004
Synonyms:
CHEMBL5282029
Type:
Small organic molecule
Emp. Form.:
C17H24ClFO7S
Mol. Mass.:
426.885
SMILES:
[Cl-].[H][C@@]1(OC(OC[C@H]1O)c1ccccc1F)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO |r|
Structure:
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